Key result
Parenteral methylcellulose induces massive splenomegaly and hemolytic anemia via splenic macrophage infiltration and stasis.
Why the study?
Parenteral administration of methylcellulose causes massive splenomegaly and hemolytic anemia in rats, but the underlying cellular changes are not fully characterized.
Rat methylcellulose model of splenomegaly and hemolysis should not guide clinical practice; leaves open translational relevance to human hemolytic anemias.
Parenteral administration of methylcellulose causes massive splenomegaly and hemolytic anemia in rats. The red pulp of the spleen is markedly cellular due mainly to: (1) large numbers of voluminous free macrophages containing methylcellulose‐induced vacuoles, (2) an increase in the number of plasma cells and (3) stasis of blood evidenced by a large number of erythrocytes and platelets in vessels, sinuses and cords. White pulp changes are usually less marked. Here the major change is the presence of macrophages containing methylcellulose‐induced inclusions. The slow circulatory time in the spleen and the increase in macrophages may cause the hemolytic anemia observed in these animals.
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Wennberg et al. (1967) studied Splenomegaly and hemolytic anemia. Parenteral administration of methylcellulose was evaluated on Cellular changes in the spleen and blood. Parenteral administration of methylcellulose in rats causes massive splenomegaly and hemolytic anemia characterized by increased macrophages, plasma cells, and blood stasis in the spleen.
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