Key result
Maternal PCOS linked to ~22% higher offspring congenital heart defect risk, attenuated by maternal diabetes.
Why the study?
Maternal PCOS may increase offspring risk of congenital heart defects due to associated insulin resistance and pregestational diabetes, but this association is unclear.
Does maternal PCOS increase the risk of congenital heart defects in offspring?
Cohort (n=1,302,648)
Does maternal PCOS increase the risk of congenital heart defects in offspring?
Odds Ratio: 1.22 (95% CI 1.03–1.44)
Absolute Event Rate: 1.21% vs 0.99%
Maternal PCOS is not strongly associated with an increased risk of congenital heart defects in offspring, providing reassurance for clinical counseling.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Schmidt et al. (2020) conducted a cohort in Congenital heart defects (n=1,302,648). Maternal polycystic ovary syndrome (PCOS) vs. Mothers without PCOS was evaluated on Congenital heart defects in offspring (PR 1.22, 95% CI 1.03-1.44). Maternal PCOS was associated with a prevalence ratio of 1.22 (95% CI 1.03-1.44) for offspring congenital heart defects, which attenuated to 1.16 (95% CI 0.98-1.37) after adjusting for diabetes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: