Key result
Positive social feedback acutely elevated positive mood and ventral striatum activation in both groups, but only healthy controls sustained positive mood over time, accompanied by reciprocal corticostriatal connectivity.
Why the study?
Does naturalistic positive mood induction alter corticostriatal pathway activation differently in healthy controls compared to individuals with a history of depression?
Case-Control (n=60)
No
Does naturalistic positive mood induction alter corticostriatal pathway activation differently in healthy controls compared to individuals with a history of depression?
p-value: p=0.003
Corticostriatal pathways contribute to the natural time course of positive mood fluctuations, and disturbances in these neural interactions may characterize mood disorders.
Impaired mood maintenance after positive feedback may reflect disrupted corticostriatal connectivity in remitted depression; leaves open causal role and clinical utility.
The natural time course of mood includes both acute responses to stimuli and spontaneous fluctuations. To date, neuroimaging studies have focused on either acute affective responses or spontaneous neural fluctuations at rest but no prior study has concurrently probed both components, or how mood disorders might modulate these processes. Here, using fMRI, we capture the acute affective and neural responses to naturalistic positive mood induction, as well as their spontaneous fluctuations during resting states. In both healthy controls and individuals with a history of depression, our manipulation acutely elevates positive mood and ventral striatum activation. Only controls, however, sustain positive mood over time, and this effect is accompanied by the emergence of a reciprocal relationship between the ventral striatum and medial prefrontal cortex during ensuing rest. Findings suggest that corticostriatal pathways contribute to the natural time course of positive mood fluctuations, while disturbances of those neural interactions may characterize mood disorder.
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Admon et al. (2015) conducted a case-control in Remitted recurrent major depressive disorder (rMDD) (n=60). Naturalistic positive mood induction (humor and positive social feedback) vs. Healthy controls vs rMDD was evaluated on Sustained positive mood (Group by Time interaction) (p=0.003). Positive social feedback acutely elevated positive mood and ventral striatum activation in both groups, but only healthy controls sustained positive mood over time, accompanied by reciprocal corticostriatal connectivity.
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