Studies on chemotherapeutics I. Synthesis of 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acid derivatives

Ethyl 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylates were synthetized by reacting 1,3,5‐triazine with 4‐substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The l‐alkyl‐5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acids required for the antimicrobial studies were prepared by N‐alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters.