Key result
Preexisting arteriosclerosis links to fewer untoward effects during induced myocardial necrosis in breeder rats.
Why the study?
The myocardial response to drug-induced necrosis in rats with varying degrees of arteriosclerosis and its physiological correlates were not well characterized.
Population
Virgin Sprague-Dawley rats without arteriosclerosis and breeder Sprague-Dawley rats with arteriosclerosis
Comparison
Virgin rats receiving 50 mg/100 g isoproterenol vs breeder rats receiving 25 mg/100 g isoproterenol
Design
Preclinical experimental study
Authors
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Rats with preexisting arteriosclerosis tolerated induced necrosis better than those without; leaves open relevance to human coronary disease.
Preexisting arteriosclerosis in rats may confer some protection against drug-induced myocardial necrosis, possibly through the development of collateral coronary circulation.
Wexler et al. (1967) studied Drug-Induced Myocardial Necrosis and Arteriosclerosis. Isoproterenol vs. Virgin nonarteriosclerotic rats vs breeder arteriosclerotic rats was evaluated on Responses to myocardial necrosis (untoward effects, adrenocortical activity, serum transaminases, lipid metabolism). Breeder rats with preexisting arteriosclerosis withstood isoproterenol-induced myocardial necrosis with fewer untoward effects than nonarteriosclerotic virgin rats.
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