Key result
Postmenopause in metabolic syndrome is linked to a ~61% smaller nighttime systolic BP dip.
Why the study?
The influence of menopause on nighttime blood pressure decrease in women with metabolic syndrome was unclear.
Does postmenopause reduce the blood pressure decrease level during nighttime in women with metabolic syndrome?
Case-Control (n=84)
Does postmenopause reduce the blood pressure decrease level during nighttime in women with metabolic syndrome?
Absolute Event Rate: 4.4% vs 11.3%
p-value: p=0.011
Postmenopause is associated with an insufficient systolic blood pressure decrease during nighttime in women with metabolic syndrome, which may contribute to increased cardiovascular risk.
Postmenopause was associated with reduced nocturnal systolic BP dipping in metabolic syndrome; hypothesis-generating for targeted ABPM studies.
Aim. To study if menopause influences the blood pressure (BP) decrease level during nighttime in women with metabolic syndrome. Methods. 84 women with metabolic syndrome are examined, from them 52 are in postmenopause (average age is 56 [SD 5] years) and 32 are in premenopause (average age is 44 [5] years). Anthropomorphic measurements were made, levels of office BP and heart rate were assessed, ambulatory BP monitoring was carried out, lipids and glucose of blood serum were studied. Results. Clinical parameters, characterizing metabolic syndrome, didn’t vary between the groups. Number of patients with insufficient decrease of BP in postmenopausal women didn’t differ significantly from the number of such women in premenopausal period (for systolic BP: 64% versus 52%, p=0,288; for diastolic BP: 34% versus 42%, p=0,469). Nevertheless, when evaluating the level of systolic BP decrease during nighttime as continuous variable, significant differences between groups are revealed (M±SEM [95% CI]: 4.4±1.5% [1.4-7.3] in postmenopausal women versus 11.3±1.7% [7.9-14.8] in premenopausal women, p=0,011). Conclusion. Postmenopause associates with insufficient systolic BP decrease during nighttime in women with metabolic syndrome.
No takes yet. Share an insight, caveat, or question.
Аничков et al. (2005) conducted a case-control in Metabolic syndrome (n=84). Postmenopause vs. Premenopause was evaluated on Level of systolic blood pressure decrease during nighttime (p=0.011). Postmenopause in women with metabolic syndrome was associated with a significantly lower nighttime systolic blood pressure decrease compared to premenopause (4.4% vs 11.3%; p=0.011).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: