Synthesis of Vinca Alkaloids and Related Compounds, XV1) A New Synthetic Route to (+)‐Vincaminic and (+)‐Apovincaminic Esters

Esters of types 7 and 8, possessing excellent vasodilating effects, have been prepared. A method has been found for the resolution of methyl ester 7c. A new method is described for the preparation of the lactam (+)‐10 and its conversion to the oxime (+)‐11, from which (+)‐vincamine (1a) and the (+)‐apovincaminic esters 2a,b were synthesized.