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August 1, 1983Journal of Medicinal Chemistry

Synthesis and antibacterial activity of some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives

John P. Dirlam Joseph E. Presslitz Brian J. Williams

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Abstract

Some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives (1) have been synthesized and screened for antibacterial activity. 2-Acetyl-3-[(methylsulfonyl)methyl]quinoxaline 1-oxide (7a) was found to possess good in vitro activity against some pathogens important to veterinary medicine including Treponema hyodysenteriae, a causative agent in swine dysentery. In an in vivo experiment, this compound (7a) completely protected pigs against a swine dysentery challenge over a 21-day period.

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Dirlam et al. (1983) studied this question.

synapsesocial.com/papers/6ab4bf5d440a6c2f224d1ad1 https://doi.org/10.1021/jm00362a007

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