Key result
ACE I allele is linked to panic disorder in male patients.
Why the study?
Angiotensin may be involved in the control of respiration, heart rate variability, and anxiety-like behavior, motivating investigation of its gene polymorphisms in panic disorder.
Are polymorphisms in angiotensin-related genes associated with panic disorder?
Case-Control (n=576)
Are polymorphisms in angiotensin-related genes associated with panic disorder?
p-value: p=0.005
The ACE I/D polymorphism I allele may be associated with panic disorder in men, providing preliminary evidence for a genetic link between the angiotensin system and anxiety-like behavior.
ACE I allele may associate with panic disorder in men; hypothesis-generating for angiotensin genes in autonomic and anxiety phenotypes.
Enhanced respiratory variability and decreased heart rate variability have repeatedly been observed in patients with panic disorder. Prompted by the notion that angiotensin may be involved in the control of respiration, heart rate variability, and anxiety-like behavior, we investigated the putative association between polymorphisms in three angiotensin-related genes and panic disorder-angiotensinogen (AGT), angiotensin converting enzyme (ACE), and angiotensin II (ANG II) receptor type 1 (ATr1) in 72 patients with panic disorder and 504 controls. Allele and genotype distribution of the ATr1 A1166C allele and the AGT M235T did not differ between patients and controls. With respect to the ACE I/D polymorphism, the I allele was found to be more frequent in male (chi(2) = 8.042, df = 1, P = 0.005), but not female, panic disorder patients than in controls. The results of this investigation provide preliminary evidence for the suggestion that angiotensin-related genes may be associated with panic disorder in men.
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Olsson et al. (2004) conducted a case-control in Panic disorder (n=576). Polymorphisms in angiotensin-related genes (AGT, ACE, ATr1) vs. Controls was evaluated on Allele and genotype distribution of ATr1 A1166C, AGT M235T, and ACE I/D polymorphisms (p=0.005). The ACE I allele was significantly more frequent in male patients with panic disorder compared to controls (P=0.005), suggesting an association between angiotensin-related genes and panic disorder.
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