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The sonic hedgehog (SHH) pathway is activated in basal-cell carcinoma, and loss-of-function mutations in SHH cause holoprosencephaly. This study uncovers a translocation involving the SHH promoter in a person with holoprosencephaly and basal-cell carcinomas.
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Gomez‐Ospina et al. (2012) studied this question.
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