Key result
Weight-stable patients with a BMI of 28-35 kg/m2 after Roux-en-Y gastric bypass or duodenal switch maintained a fat-free mass percentage (58% and 61%, respectively) similar to non-operated controls (58%).
Why the study?
Does bariatric surgery (RYGB or BPD/DS) lead to excessive loss of fat-free mass and resting metabolic rate compared to non-operated controls in weight-stable patients?
Cross-Sectional (n=44)
No
Does bariatric surgery (RYGB or BPD/DS) lead to excessive loss of fat-free mass and resting metabolic rate compared to non-operated controls in weight-stable patients?
Absolute Event Rate: 57.6% vs 58%
p-value: p=0.972
Weight-stable patients after RYGB and BPD/DS maintain a body composition and resting metabolic rate similar to non-operated individuals of the same BMI.
Supports preserved fat-free mass post-bypass in stable patients; leaves open causality and need for prospective trials.
Concerns for the possibility of an excessive loss of fat-free mass (FFM) and resting metabolic rate (RMR) after bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and duodenal switch (BPD/DS), have been raised. This study aims to examine body composition and RMR in patients after RYGB and BPD/DS and in non-operated controls. Body composition and RMR were studied with Bod Pod and indirect calorimetry in weight-stable RYGB ( n = 15) and BPD/DS patients ( n = 12) and compared with non-operated controls ( n = 17). All patients were 30–55 years old and weight stable with BMI 28–35 kg/m 2 . FFM% was 58% (RYGB), 61% (BPD/DS), and 58% (controls). Body composition did not differ after RYGB and BPD/DS compared to controls, despite 27 and 40% total body weight loss, respectively. No difference in RMR or RMR/FFM was observed (1539, 1617, and 1490 kcal/24 h; and 28.9, 28.4, and 28.8 kcal/24 h/kg). Weight-stable patients with BMI 28–35 kg/m 2 after RYGB and BPD/DS have a body composition and RMR similar to that of non-operated individuals within the same BMI interval.
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Skogar et al. (2016) conducted a cross-sectional in Obesity (post-bariatric surgery) (n=44). Bariatric surgery (Roux-en-Y gastric bypass or duodenal switch) vs. Non-operated controls was evaluated on Fat-free mass percentage (FFM%) (p=0.972). Weight-stable patients with a BMI of 28-35 kg/m2 after Roux-en-Y gastric bypass or duodenal switch maintained a fat-free mass percentage (58% and 61%, respectively) similar to non-operated controls (58%).