Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins

All articles of this category A new synthetic route in phenytoin and 5,5-diarylhydantoins is reported. Parabanic acid is converted to the 5,5-diarylhydantoins (65-98% yield) from CF 3 SO 3 H and arenes. Deuterium substituted produts are prepared in high yield from parabanic acid, CF 3 SO 3 D, and deuterated arenes. phenytoin - hydantoin - heterocycle - superacid - electrophile