Key result
GSDME, caspase-3, and caspase-8 were more highly expressed in lung tumor tissues than adjacent normal tissues, and GSDME expression positively correlated with postoperative survival.
Why the study?
Do the expression levels of caspase-3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer?
Observational (n=100)
Do the expression levels of caspase-3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer?
GSDME is highly expressed in lung cancer tissues and positively correlates with postoperative survival, suggesting it may serve as an independent prognostic factor.
GSDME expression was associated with better postoperative survival in lung cancer; hypothesis-generating for its prognostic value, needs prospective validation.
BACKGROUND: Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial. AIM: The goal of this study was to determine whether the expression levels of caspase-3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer. METHODS: We examined the protein levels of GSDME, caspase-3, caspase-8, and caspase-9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry. RESULTS: We found that GSDME, caspase-3, and caspase-8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer. CONCLUSIONS: GSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research.
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Huang et al. (2021) conducted an observational in Lung cancer (n=100). GSDME and caspase expression vs. Adjacent normal tissues was evaluated on Clinical stage, pathological grade, and survival prognosis. GSDME, caspase-3, and caspase-8 were more highly expressed in lung tumor tissues than adjacent normal tissues, and GSDME expression positively correlated with postoperative survival.
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