Key result
Nitroglycerin ointment applied daily was as effective as estrogen replacement therapy in preventing bone loss over 1 year in women following oophorectomy.
Why the study?
Does nitroglycerin ointment prevent bone loss in women following oophorectomy compared to estrogen replacement therapy?
Population
Women who underwent oophorectomy (surgically induced menopausal women)
Comparison
Nitroglycerin ointment applied to the skin once… vs Standard estrogen replacement therapy
Design
RCT, Randomized
Follow-up
1 year
Authors
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NG may prevent estrogen-deficiency bone loss; hypothesis-generating pilot data requiring larger confirmatory trials.
RCT
randomized
Does nitroglycerin ointment prevent bone loss in women following oophorectomy compared to estrogen replacement therapy?
Nitroglycerin ointment may be as effective as estrogen replacement therapy in preventing bone loss in women following oophorectomy.
Sunil J. Wimalawansa (2000) conducted an RCT in oophorectomy-induced bone loss. Nitroglycerin (NG) ointment vs. Estrogen replacement therapy (Premarin) was evaluated on Bone mineral density (BMD). Nitroglycerin ointment applied daily was as effective as estrogen replacement therapy in preventing bone loss over 1 year in women following oophorectomy.