Key result
Cardiovascular drugs alter the extent and direction of cardiorespiratory interdependences in rats.
Why the study?
The effects of drugs on the interdependence between cardiac interval variability, respiratory activity, and systolic pressure in cardiovascular control are not fully understood.
We made use of multivariate nonlinear analysis methods to study the interdependence between the cardiac interval variability and both the respiratory activity and the systolic pressure in rats. The study was carried out in basal conditions and after the application of different drugs affecting the cardiovascular system. The results showed that there are changes both in the extent and in the directionality of such interdependences because of the drugs. The inhibition of the NO and the parasympathetic blockade changed the cardiovascular coordination, with the latter one also modifying the interdependence between the cardiac interval and the respiratory signal. This suggests that the nonlinear approach might be very helpful to explore the interaction between subsystems of the cardiovascular control system.
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Pereda et al. (2005) studied this question. Cardiovascular drugs (NO inhibition and parasympathetic blockade) vs. Basal conditions was evaluated on Interdependence between cardiac interval variability, respiratory activity, and systolic pressure. Application of cardiovascular drugs, including NO inhibition and parasympathetic blockade, altered the extent and directionality of cardiovascular and cardiorespiratory interdependences in rats.
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