Key result
Biotemplated nanopatterning using reconstituted microtubules successfully generated dense, structurally oriented arrays of functional motor proteins that efficiently guided microtubule transporters.
Demonstrates a highly efficient method for generating nanometer-wide protein patterns on planar surfaces to guide microtubule transporters.
Enables oriented motor protein arrays for molecular transport; leaves open translation to cardiovascular nanodevices.
We report on the generation of nanometer-wide, non-topographical patterns of proteins on planar surfaces. In particular, we used the regular lattice of reconstituted microtubules as template structures to specifically bind and transfer kinesin-1 and nonclaret disjunctional motor proteins. The generated tracks, which comprise dense and structurally oriented arrays of functional motor proteins, proved to be highly efficient for the guiding of microtubule transporters.
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Reuther et al. (2006) studied this question. Biotemplated nanopatterning using reconstituted microtubules was evaluated on Generation of nanometer-wide, non-topographical patterns of proteins on planar surfaces and guiding of microtubule transporters. Biotemplated nanopatterning using reconstituted microtubules successfully generated dense, structurally oriented arrays of functional motor proteins that efficiently guided microtubule transporters.
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