months resulted in early and continued overall improvement.The stools became firmer and the frequency reduced to two or three a day.There was relief of the abdominal pain and discomfort.His weight has remained constant at 8-st.(55 kg.).He has been maintained for 11 months on one tablet t.d.s. with no evidence of tolerance developing, and now has returned to his normal work as a garage mechanic.My thanks to Dr. B.
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Seedat et al. (1970) studied this question.