Key result
Juvenile male cynomolgus monkeys show higher alkaline phosphatase and lower BUN versus adults, with unchanged EKG parameters.
Why the study?
Age-related changes in serum biochemical and EKG values in cynomolgus macaques were characterized to establish normal reference ranges.
Key points are not available for this paper at this time.
Comparison
Juvenile vs adult male cynomolgus monkeys
Design
Other study design
Requires age-adjusted reference ranges for juvenile primates in preclinical research; leaves open translation to human cardiovascular studies.
Normal serum values for alkaline phosphatase were significantly higher in juvenile male cynomolgus monkeys compared to adults. Conversely, blood urea nitrogen (BUN) was significantly lower in juveniles than adults. A comparison of selected EKG parameters from each group revealed no significant differences; however, there was a trend towards mean left axis deviation in adult animals.
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Kapeghian et al. (1984) studied this question. Juvenile male cynomolgus monkeys had significantly higher alkaline phosphatase and lower blood urea nitrogen than adults, with no significant differences in EKG parameters.
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