[structure: see text]. A highly convergent, enantioselective synthesis of (+) -Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.
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Wilson et al. (2007) studied this question.
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