Key result
The T allele at the RORC:g.3290T > G SNP significantly increased both marbling score (P=0.033) and intramuscular fat (P=0.018) across Angus, Brahman, and Hereford cattle breeds.
Observational (n=2,741)
The T allele at the SNP RORC:g.3290T > G is associated with increased marbling score and intramuscular fat in Australian cattle.
Variation at the retinoic acid receptor-related orphan receptor C (RORC) gene was previously associated with marbling score in a large sample of Australian taurine feedlot cattle of Angus and Shorthorn breeds. The T allele at the SNP RORC:g.3290T > G increased marbling score in Angus and Shorthorn cattle. We genotyped this SNP in an independent sample of 2,741 Australian cattle of Angus, Brahman, and Hereford breeds, and tested the association of this SNP with marbling score in all animals and with intramuscular fat (IMF) measurements in 2,104 animals. We found an allele frequency of the G allele of p(G) = 0.57 in Angus, p(G) = 0.09 in Hereford, and p(G) = 0.64 in Brahman. The regression of marbling score against number of copies of the G allele was significant (P = 0.033) in the combined sample after accounting for ancestry, breed, and the contemporary group structure of the data. All breeds had the same favorable homozygote; the regression on alleles showed a trend in Angus and Brahman cattle (P < 0.1), but not in Hereford cattle (P = 0.912). The regression of IMF against number of copies of the G allele was significant (P = 0.018) after accounting for ancestry, breed, and contemporary group structure. All breeds had the same favorable homozygote and the regression on alleles was significant (P = 0.024) in the Angus breed. In all breeds tested in this study, the T allele increased both marbling score and IMF. This polymorphism explained 0.3% of the phenotypic variance for IMF in this sample.
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Barendse et al. (2009) conducted an observational in Healthy cattle (n=2,741). Variation at the retinoic acid receptor-related orphan receptor C (RORC) gene (SNP RORC:g.3290T > G) vs. Alternative alleles was evaluated on Marbling score and intramuscular fat (IMF) measurements (p=0.033). The T allele at the RORC:g.3290T > G SNP significantly increased both marbling score (P=0.033) and intramuscular fat (P=0.018) across Angus, Brahman, and Hereford cattle breeds.
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