Key result
Peripheral infusion of L-tryptophan significantly increased cerebrospinal fluid serotonin and plasma growth hormone concentrations in cattle, suggesting GH release via serotonergic neuron activation.
Why the study?
Does L-tryptophan infusion increase growth hormone secretion via central serotonin activation in cattle?
Population
Cattle and dispersed bovine anterior pituitary cells
Comparison
L-tryptophan infusion vs Baseline conditions
Design
Preclinical
Follow-up
7 hours (sampling from 11.00 to 18.00 hours)
Authors
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TRP-induced GH release in cattle is centrally mediated by serotonin; hypothesis-generating for pituitary regulation in ruminants.
Does L-tryptophan infusion increase growth hormone secretion via central serotonin activation in cattle?
L-tryptophan induces growth hormone release in cattle through the activation of central serotonergic neurons rather than a direct effect on the pituitary.
Kasuya et al. (2010) studied this question. L-tryptophan (TRP) was evaluated on Changes in 5-HT concentrations in the cerebrospinal fluid and GH in plasma. Peripheral infusion of L-tryptophan significantly increased cerebrospinal fluid serotonin and plasma growth hormone concentrations in cattle, suggesting GH release via serotonergic neuron activation.
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