Key result
Pteropine orthoreovirus IgG antibodies were detected in 12 (4.4%) of 272 human serum samples from Central Vietnam, with neutralizing antibodies confirmed in 6 cases.
Cross-Sectional (n=272)
This study provides the first serological evidence of human infection with Pteropine orthoreovirus in Central Vietnam, highlighting the need for regional surveillance.
Seropositivity in Central Vietnam extends known range; leaves open clinical significance and need for surveillance studies.
Pteropine orthoreovirus, potentially of bat origin, has been reported to cause respiratory tract infections among human beings in Southeast Asia. Twelve IgG ELISA-positive cases with antibodies against Pteropine orthoreovirus were detected among 272 human serum samples collected between March and June 2014 from in and around Hue City, Central Vietnam. These 12 cases were IgM ELISA negative. Neutralizing antibodies were also detected among six of these cases with the highest titer of 1:1,280 in 2 cases (both female, 32 and 68 years old, respectively). This is the first report of human infection with Pteropine orthoreovirus in Central Vietnam. These findings indicate the need for surveillance on Pteropine orthoreovirus infections in Southeast Asia to enable prevention and control strategies to be developed should a change in virulence occur.
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Singh et al. (2015) conducted a cross-sectional in Pteropine orthoreovirus infection (n=272). Pteropine orthoreovirus exposure was evaluated on IgG antibodies against Pteropine orthoreovirus. Pteropine orthoreovirus IgG antibodies were detected in 12 (4.4%) of 272 human serum samples from Central Vietnam, with neutralizing antibodies confirmed in 6 cases.
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