An organocatalytic vinylogous Friedel-Crafts alkylation-initiated formal [2+2] cycloaddition was successfully developed based on tandem iminium-enamine activation of enals. Transformable pyrrole-functionalized cyclobutanes with three contiguous stereocenters were readily obtained with excellent levels of regio-, diastereo- and enantiocontrol.
No takes yet. Share an insight, caveat, or question.
Duan et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: