Key result
Sepsis was associated with significantly higher initial microalbuminuria levels (152.01 mg/g) compared to non-sepsis (81.4 mg/g) in ICU patients.
Why the study?
Does microalbuminuria measurement accurately differentiate sepsis from non-sepsis and predict mortality in ICU patients?
Observational (n=150)
No
Does microalbuminuria measurement accurately differentiate sepsis from non-sepsis and predict mortality in ICU patients?
Microalbuminuria is a highly sensitive and specific biomarker for the early detection of sepsis in ICU patients, outperforming standard APACHE II and SOFA scores.
Microalbuminuria may stratify ICU mortality risk; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Sepsis is an important healthcare concern in India as well as globally.This study demonstrates how the mortality of patients with and without sepsis is predicted by the degree of microalbuminuria.Methods: In this study total 150 patients of which 75 patients belonging to each sepsis and non-sepsis group, with age >15 years admitted in Intensive Care Unit (ICU).We have analysed Microalbuminuria levels at the time of admission and after 24 hours of admission.Results: Compared to non-septic patients, patients with sepsis had noticeably higher levels of microalbuminuria.Compared to APACHE II and SOFA scores, microalbuminuria has the highest sensitivity (90%) and specificity (98%) for differentiating between sepsis and non-sepsis.Conclusion: Sequential monitoring of urine albumin-creatinine measurements at the bedside may aid in the early detection of sepsis patients in need of early targeted therapy.In addition to predicting ICU survival, the 24-hour ACR evaluation may be used to track the effectiveness of therapeutic measures administered, including fluid resuscitation, the right antibiotics, vasopressors, and ionotropes that impact the endothelium.
No takes yet. Share an insight, caveat, or question.
Kodala Prashant Mansukhla Rajeev (2024) conducted an observational in Sepsis (n=150). Sepsis vs. Non-sepsis was evaluated on Initial microalbuminuria level (ACR1) in mg/g (p=0.0001). Sepsis was associated with significantly higher initial microalbuminuria levels (152.01 mg/g) compared to non-sepsis (81.4 mg/g) in ICU patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: