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Purine was synthesized by heating formamide at 170-200° without any other reagent. The maximum yield was 71% calculated from consumed formamide and 20.5% calculated from formamide used. 8-Formylamino-7, 8-dihydro-9H-purine was isolated as an intermediate of purine formation and its reaction mechanism was proposed.
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Yamada et al. (1975) studied this question.
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