Synthesis of New (N α‐Dipicolinoyl)‐bis‐ L ‐valyl‐ L ‐phenylalanyl Linear and Macrocyclic Bridged Peptides as Anti‐Inflammatory Agents

In continuation to our search for new chiral macrocyclic peptide-based anti-inflammatories, the suggestion, synthesis, structure elucidation of some Nalpha-bis-dipicolinoyl amino acids, linear, tetra and cyclic (penta and octa)-bridged peptides 3-10, were realized herein. The newly synthesized compounds showed potent anti-inflammatory activity with low toxicity (LD50) comparable to indomethacin and diclofenac as reference anti-inflammatory drugs.