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September 1, 1992Journal of Medicinal Chemistry

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction

Siegfried Goldmann Juergen Stoltefuss Liborius Born

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Abstract

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.

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Goldmann et al. (1992) studied this question.

synapsesocial.com/papers/6ab5d7dfaf0d8ad41c20af7f https://doi.org/10.1021/jm00096a005

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