Immune Complexes in Cancer

Antigen–antibody immune complexes can activate a variety of cell types, interact with humoral factors, and induce the release of biologically active mediators that participate directly in disease processes. Moreover, immune complexes have profound effects on immune responses, enhancing or suppressing them, depending on the molar ratio of the antigens and antibodies that they contain.1 Therefore, the role of immune complexes in tumor immunopathology and immunity has been subjected to extensive scrutiny.Tumor cells, expressing new antigens on their surface membranes, become foreign to the host and elicit both humoral and cellular immune responses. These responses should produce a condition that . . .