Key result
Young ACS patients show high cardiovascular risk factor burden but low ~1% in-hospital mortality.
Why the study?
The impact of diabetes and smoking epidemics on the presentation and outcomes of ACS in very young patients in the Middle East was not well described.
Observational (n=8,176)
Yes
Very young patients presenting with ACS in the Middle East have high rates of modifiable risk factors like smoking and diabetes but experience low in-hospital mortality.
Supports prevention targeting smoking and diabetes in young adults; leaves open generalizability and long-term outcomes from this observational cohort.
We describe the baseline characteristics, management, and outcomes of acute coronary syndrome (ACS) in patients of age ≤ 40 in the Gulf region of the Middle East. We studied 8176 hospitalized patients (≤ 40 years) with ACS. Ten percent (805) of the recruited patients were ≤ 40 years. The mean age was 37 years and 89% were males. The prevalence of smoking and diabetes in the young patients was high (58% and 21%, respectively). The most common ACS was ST elevation myocardial infarction. Younger patients were more aggressively treated with more frequent use of glycoprotein inhibitors, thrombolytics, and primary percutaneous coronary intervention. They had less in-hospital heart failure, left ventricular dysfunction, shock, stroke, and low rate of in-hospital mortality (1%). Measures to combat the rising prevalence of diabetes and smoking are needed.
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Alanbaei et al. (2011) conducted an observational in Acute coronary syndrome (ACS) (n=8,176). Young age (≤ 40 years) vs. Older patients was evaluated on In-hospital mortality. Young patients (≤ 40 years) with acute coronary syndrome had high rates of smoking (58%) and diabetes (21%), but experienced a low in-hospital mortality rate of 1%.
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