Key result
The TC/TT genotypes of the AKT1 rs10138227 polymorphism were associated with a significantly increased risk of colorectal cancer compared to the CC homozygous genotype (OR 2.82).
Why the study?
Are AKT1 and LMTK3 polymorphisms associated with an increased risk of colorectal cancer in a Moroccan population?
Case-Control (n=120)
No
Are AKT1 and LMTK3 polymorphisms associated with an increased risk of colorectal cancer in a Moroccan population?
Odds Ratio: 2.82 (95% CI 1.15–6.91)
p-value: p=0.021
The AKT1 rs10138227 polymorphism may increase susceptibility to colorectal cancer in the Moroccan population.
AKT1 rs10138227 TC/TT genotypes may mark elevated CRC risk in Moroccans; leaves open validation in larger studies before any clinical use.
BACKGROUND: LMTK3 and AKT1 each have a role in carcinogenesis and tumor progression. The analysis of single nucleotide polymorphisms of AKT1 and LMTK3 could lead to more complete and accurate risk estimates for colorectal cancer. AIM: We evaluated the association between single nucleotide polymorphisms (SNPs) of AKT1 and LMTK3 and the risk of colorectal cancer in a case-control study in Moroccan population. METHODS: Genomic DNA from 70 colorectal cancer patients and 50 healthy control subjects was extracted from whole blood. Genotyping was performed by direct sequencing after polymerase chain reactions for the 7 SNPs (AKT1rs1130214G/T, AKT1rs10138227C/T, AKT1rs3730358C/T, AKT1rs1000559097G/A, AKT1rs2494737A/T, LMTK3rs8108419G/A, and LMTK3rs9989661A/G.). Study subjects provided detailed information during the collection. All P values come from bilateral tests. RESULTS: In the logistic regression analysis, a significantly high risk of colorectal cancer was associated with TC/TT genotypes of rs10138227 with adjusted odds ratio [OR] equal to 2.82 and 95% confidence interval [CI] of 1.15 to 6.91. CONCLUSION: Our results suggest that the SNP AKT1rs10138227 could affect susceptibility to CRC, probably by modulating the transcriptional activity of AKT1. However, larger independent studies are needed to validate our results.
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Allam et al. (2020) conducted a case-control in Colorectal cancer (n=120). AKT1 rs10138227 polymorphism (TC/TT genotypes) vs. CC homozygous genotype was evaluated on Risk of colorectal cancer (OR 2.82, 95% CI 1.15-6.91, p=0.021). The TC/TT genotypes of the AKT1 rs10138227 polymorphism were associated with a significantly increased risk of colorectal cancer compared to the CC homozygous genotype (OR 2.82).
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