Dialkylaluminium aryloxide in combination with a tertiary amine was found to be a good reagent for regioselective aldol condensation of methyl ketones at the methyl side. Regioselective aldol condensation of 2-octanone was carried out using diisobutylaluminium phenoxide–pyridine. The intramolecular aldol condensation of 2,15-hexadecanedione promoted by the same reagent gave a mixture of dehydromuscones in 65% yield. Its hydrogenation produced muscone.
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Tsuji et al. (1980) studied this question.
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