Key result
Arteriosclerosis obliterans is linked to a ~41% lower serum EPA/AA ratio vs. controls.
Why the study?
A low serum EPA/AA ratio has been associated with coronary artery disease, but its relationship with arteriosclerosis obliterans was unclear.
Is a low serum EPA/AA ratio associated with arteriosclerosis obliterans?
Case-Control (n=54)
No
Is a low serum EPA/AA ratio associated with arteriosclerosis obliterans?
Absolute Event Rate: 0.36% vs 0.61%
p-value: p=0.03
Patients with arteriosclerosis obliterans have a lower serum EPA/AA ratio compared to non-atherosclerotic controls, though this association may be confounded by the presence of diabetes.
PURPOSE: A low ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) has been associated with coronary artery disease. We retrospectively examined serum concentrations of polyunsaturated fatty acids in patients with arteriosclerosis obliterans (ASO) and in non-atherosclerotic patients. METHODS: From April 2011 to March 2012, serum EPA/AA was retrospectively examined in 33 consecutive outpatients with ASO complicated by intermittent claudication and 21 outpatients with hypercholesterolemia without ASO as controls. The Student's t-test was used for continuous variables and Chi-square test for categorical variables, with analysis of covariance adjusting for age, sex, body mass index, smoking, alcohol, and diabetes. RESULTS: The ASO group were significantly different with regard to mean age (71.5 vs. 63.9 year-old, p = 0.03), body mass index (21.3 vs. 24.1 kg/m(2), p = 0.002) and morbidity of diabetes mellitus (51.5 vs. 4.8%, p = 0.0004). Serum EPA/AA was significantly decreased in ASO (0.36 vs. 0.61, p = 0.03), when adjusted for age, sex, body mass index, smoking status and alcohol drinking, but was not statistically significant when adjusted for diabetes. CONCLUSION: Patients with ASO were more likely to have a low EPA/AA ratio and non- diabetic patients with ASO had a significantly reduced EPA/AA.
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Fukuda et al. (2013) conducted a case-control in Arteriosclerosis obliterans (n=54). Arteriosclerosis obliterans vs. Non-atherosclerotic controls with hypercholesterolemia was evaluated on Serum EPA/AA ratio (adjusted for age, sex, BMI, smoking, and alcohol) (p=0.03). Patients with arteriosclerosis obliterans had a significantly reduced serum EPA/AA ratio compared to non-atherosclerotic controls (0.36 vs. 0.61, p=0.03) after adjusting for multiple covariates.
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