The Cu( i )-catalyzed azide–alkyne cycloaddition (CuAAC) of 4′-azidothymidine ( 5 ) generated a series of 1,2,3-triazole analogues ( 9 ) with moderate anti-HIV activities, while a similar cycloaddition reaction catalyzed by Ru( ii ) failed.
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Vernekar et al. (2014) studied this question.
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