Key result
The T allele of the MCT1 T1470A polymorphism was significantly over-represented in Polish climbers compared to controls (OR 1.44), but this association was not observed in Japanese climbers.
Why the study?
Is the MCT1 T1470A polymorphism associated with climbing status in Polish and Japanese populations?
Case-Control (n=1,254)
Is the MCT1 T1470A polymorphism associated with climbing status in Polish and Japanese populations?
The MCT1 T1470A polymorphism is associated with climbing status in Polish but not Japanese populations, suggesting population-specific genetic factors in athletic performance.
Polish climbers show higher MCT1 T allele frequency than controls; leaves open generalizability and causal validation.
Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene is associated with athletic performance and physiological phenotypes. The purpose of this study was to investigate the frequency of MCT1 T1470A polymorphism in Polish and Japanese climbers using a case-control study. Our sample consisted of 226 climbers (Japanese: n = 100, 64 male and 36 female; Polish: n = 126, 97 male and 29 female) and 1028 non-athletic controls (Japanese, n = 407; Polish = 621) who were genotyped for the MCT1 T1470A polymorphism (rs1049434) using the TaqMan SNP genotyping assay or restriction enzyme. The frequency of the TT genotype and T allele was significantly higher in climbers than in controls among the Polish subjects (genotype: p = 0.030, allele: p = 0.010); however, there were no significant differences in the genotype and allelic frequencies between the Japanese climbers and controls (genotype: p = 0.968; allele: p = 0.803). Our results suggested that the frequency of the T allele (TT+TA genotype) in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. In addition, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls.
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Saito et al. (2020) conducted a case-control in Sport climbing status (n=1,254). MCT1 T1470A polymorphism vs. Non-athletic controls was evaluated on Frequency of the MCT1 T1470A T allele in climbers versus controls (Polish cohort) (OR 1.44, 95% CI 1.09-1.90, p=0.011). The T allele of the MCT1 T1470A polymorphism was significantly over-represented in Polish climbers compared to controls (OR 1.44), but this association was not observed in Japanese climbers.
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