Recent data [12] suggest that flare-up of ulcerative 1994; 18: 347-348.colitis seems to be more frequent and occur earlier in 8 Pullan RD, Rhodes J, Ganesh S, et al.Transdermal nicotine steroid-treated patients than after treatment with nicotine for active ulcerative colitis.N Engl J Med 1994; 330: patches.The reason for this phenomenon, which needs 811-815.confirmation by further studies, remains unknown, and 9 Sandborn WJ, Tremaine WJ,
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Guslandi (1999) studied this question.
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