A Randomized Single Blind Controlled Trial to Assess Postoperative Analgesia After Intraperitoneal Instillation of Lornoxicam in Laparoscopic Appendectomy

INTRODUCTION:The laparoscopic surgeries though results in less postoperative pain it is not a pain-free procedure and early postoperative pain is the most dominant complaint which requires strong analgesia.This study assessed post-operative analgesia after intraperitoneal instillation of lornoxicam in laparoscopic appendicectomy.METHODS: This single blind randomized controlled trial was done in a tertiary care Centre of North Karnataka from January 2014 to December 2014.A total of 60 patients scheduled for laparoscopic appenticectomy were randomly assigned into two groups of 30 each (Group A and B) using computer generated random numbers.Patients in group A received intraperitoneal instillation of 8 mg lornoxicam (Diluted in 100 ml of normal saline) and in group B patients received 100 ml of intraperitoneal normal saline.During the post-operative period pain and requirement of analgesia were assessed.RESULTS: The demographic characteristics, clinical presentation and preoperative evaluation for vitals was comparable in group A and B. The mean VAS score were significantly low in group A compared to group B at fourth, sixth, eight and twelfth hour interval (p<0.050).In patients with group B, the requirement of analgesia was high (53.33%)compared to group A (33.33%) (p=0.118).CONCLUSION: The intraperitoneal instillation of lornoxicam is simple analgesic technique that reduces the pain without adverse effects compared to normal saline.