Key result
HIV infection in patients presenting with acute coronary syndrome was associated with a significantly higher rate of 30-day major adverse cardiac and cerebrovascular events compared to HIV-negative controls (26.6% vs. 7%, p=0.021).
Why the study?
People living with HIV have increased cardiovascular risk and unclear short-term prognosis after acute coronary syndrome, with limited data on clinical and angiographical features in this population.
Case-Control (n=100)
Yes
This study aims to characterize the clinical profile, angiographic features, and short-term prognosis of acute coronary syndrome in Romanian patients living with HIV.
May warrant enhanced short-term vigilance in HIV-ACS; leaves open whether targeted strategies improve outcomes.
People living with human immunodeficiency virus have increased cardiovascular risk due to a higher prevalence of traditional and particular risk factors such as chronic inflammation, immune dysregulation, endothelial dysfunction, coagulation abnormalities and antiretroviral therapy. In developed countries, coronary artery disease has become the most frequent cardiovascular disease and an important cause of mortality in these patients. The symptomatology of an acute coronary syndrome can be atypical, and the prevalence of each type of acute coronary syndrome is reported differently. Regarding coronary artery disease severity in people living with HIV, the literature data indicates that the presence of single-vessel disease is akin to that of HIV-negative patients, and their short-term prognosis is unclear. This study aims to assess the clinical characteristics, biological parameters, angiographical features and short-term prognosis of acute coronary syndrome in a cohort of Romanian people living with human immunodeficiency virus.
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Bajdechi et al. (2023) conducted a case-control in Acute Coronary Syndrome (n=100). HIV infection vs. HIV-negative controls was evaluated on 30-day major adverse cardiac and cerebrovascular events (MACCE) (p=0.021). HIV infection in patients presenting with acute coronary syndrome was associated with a significantly higher rate of 30-day major adverse cardiac and cerebrovascular events compared to HIV-negative controls (26.6% vs. 7%, p=0.021).
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