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January 1, 1979Journal of Medicinal Chemistry

Actions of two dopamine derivatives at adreno- and cholinoceptors

I. W. Rodger Andrew Hersom R. D. WAIGH

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Abstract

Salsolinol (1)and 6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (2) were synthesized and their effects at adreno- and cholinoceptors investigated both in vivo and in vitro. Both 1 and 2 produced agonist effects at cholinoceptors and alpha- and beta-adrenoceptors. Neuromuscular blocking actions were evident in vitro. Compound 2 exhibited anticholinesterase properties both in vivo and in vitro. These results indicate that dopamine derivatives of this type exhibit not only sympathomimetic activity but also complex actions at cholinoceptors.

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Rodger et al. (1979) studied this question.

synapsesocial.com/papers/6ab5e97bf9c131273620b150 https://doi.org/10.1021/jm00187a027

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