Kinetic and Biological Studies of Nickel(II) and Copper(II) Macrocyclic Complexes

Macrocyclic ligands offer an efficient means to modify metal complex geometry, to regulate its kinetics, electronic structure, and reactivity. Here, the kinetic studies of [MIIL]Cl2 tetraazamacrocyclic complexes (M = Ni and Cu, and L is dichloro-[2,4,9,13,15,20-hexamethyldibenzo-1,4,8,11-tetraazacyclotetra-decatetraene]) have been taken into the account. The kinetic data have indicated the greater inertness of the macrocyclic ligands towards NiII/CuII transition metals. This is attributed to the alteration in the coordination environment of metal octahedral to square planar conformation. The result is compatible with the solvating process of released metal ion and macrocyclic ligands. In addition, the biological activity of both the complexes against Gram +ve and Gram –ve bacteria has been carried out. The results indicate that the CuII complex can be served as a potential model for antimicrobial activity against the Gram +ve and Gram –ve bacteria.