Key result
Slow-infusion furosemide increases total natriuretic response ~40% compared to bolus administration.
Why the study?
The influence of the rate of delivery of frusemide to its site of action on the drug's effect and efficiency was not well understood.
Does slowing the delivery of furosemide improve natriuretic efficiency and response in healthy volunteers?
Comparison
Frusemide 30 mg bolus dose vs slow-rate infusion vs bolus dose with 2 g probenecid
Design
Three-way cross-over study
Follow-up
10 hours
Authors
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Delivery rate may influence frusemide natriuresis in healthy volunteers; hypothesis-generating and should not yet change practice.
RCT (n=7)
Does slowing the delivery of furosemide improve natriuretic efficiency and response in healthy volunteers?
Effect estimate: 40% higher
p-value: p=<0.001
Slowing the delivery of furosemide to its site of action increases its natriuretic efficiency and overall natriuretic response compared to a standard bolus dose.
Wakelkamp et al. (1997) conducted an RCT in Healthy (n=7). Frusemide slow-rate infusion vs. Frusemide bolus dose was evaluated on Total natriuretic response (40% higher, p=<0.001). Frusemide administered as a slow-rate infusion increased total natriuretic response by 40% compared to a bolus dose (P<0.001).
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