N-O diheterocyclic nucleosides: Synthesis of 2′-n-methyl-3′-hydroxymethyl-1′,2′-isoxazolidinylthymidine

Isoxazolidine thymidine derivatives were synthesized by the condensation of silylated thymine with isoxazolidinyl acetate prepared by the Michael addition of an α,β-unsaturated ester with N-methylhydroxyamine followed by DIBAL reduction and acetate production.