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February 12, 2011Applied and Environmental MicrobiologyOpen Access

The Probiotic Escherichia coli Nissle 1917 Reduces Pathogen Invasion and Modulates Cytokine Expression in Caco-2 Cells Infected with Crohn's Disease-Associated E. coli LF82

Claudia Hüebner Yaoyao Ding Ivonne Petermann Christoph Knapp Lynnette R. Ferguson

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Abstract

Increased numbers of adherent invasive Escherichia coli (AIEC) have been found in Crohn's disease (CD) patients. In this report, we investigate the potential of the probiotic Escherichia coli Nissle 1917 (EcN) to reduce features associated with AIEC pathogenicity in an already established infection with AIEC reference strain LF82.

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Hüebner et al. (2011) studied this question.

synapsesocial.com/papers/6ab5f4ae90afbcc1ad0e44ec https://doi.org/10.1128/aem.01601-10

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn diseaseCase-Control Study · 2007 · 589 citations
2Culture independent analysis of ileal mucosa reveals a selective increase in invasive <i>Escherichia coli</i> of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileumOriginal Research · 2007 · 630 citations
3Type 1 pili‐mediated adherence of <i>Escherichia coli</i> strain LF82 isolated from Crohn's disease is involved in bacterial invasion of intestinal epithelial cellsOriginal Research · 2001 · 223 citations
4Inhibitory effect of probiotic <i>Escherichia coli</i> strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent–invasive <i>E. coli</i> strains isolated from patients with Crohn's diseaseIn Vitro Study · 2003 · 206 citations
5A Molecular Strategy for the Study of Bacterial InvasionOriginal Research · 1987 · 54 citations

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