Feeding deterrent activities of twelve clerodane diterpenoids towards Tenebrio molitor (Coleoptera: Tenebrionidae) larvae have been correlated using molecular connectivity indexes (3χc, 4χc, °ΔX) and hydrophobicity constants (log K′w) obtained by reverse‐phase liquid chromatography (RPLC). The equations obtained suggest that both the degree of branching and the electronic characteristics of the compounds under study have a dominant role in the observed antifeedant activity. The information obtained from the correlations should be useful in designing more potent analogues.
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Luco et al. (1994) studied this question.
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