ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. Biological and clinical findings

Sabina Chiaretti; Akram Taherinasab; Irene Della Starza; Martina Canichella; Michela Ansuinelli; Maria Stefania De Propris; Monica Messina; Orietta Spinelli; Alessandra Santoro; Lucia Anna De Novi; Deborah Cardinali; Mattia Schipani; Valentina Arena; Renato Bassan; Anna Rita Guarini; Robin Foà

doi:10.1080/10428194.2022.2148217

December 19, 2022Leukemia & lymphoma/Leukemia and lymphomaOpen Access

ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. Biological and clinical findings

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Key Points

To characterize novel fusion genes and determine the biological and clinical relevance of ZNF384 rearrangements in adult Philadelphia chromosome-negative and Ph-like-negative B-other acute lymphoblastic leukemia.
Applied genome-wide sequencing technologies to profile fusion genes in adult B-cell precursor acute lymphoblastic leukemia (B-ALL).
Screened and evaluated adult patients classified as 'B-other' ALL who lacked standard Ph-negative and Ph-like recurring genetic abnormalities.
Identified ZNF384 rearrangements as the most frequent recurrent genetic lesion in adult Ph-negative and Ph-like-negative B-other acute lymphoblastic leukemia.
Demonstrated that ZNF384 fusion genes delineate a distinct biological and clinical subgroup within previously unclassified B-ALL.

Implication

Genetic analysis reveals ZNF384 rearrangements as the primary lesion in adult Ph-negative B-other ALL, highlighting a distinct subtype for targeted management.

Abstract

Genome-wide technologies identified novel fusion genes in B-cell precursor acute lymphoblastic leukemia (B-ALL), refining the genetic characterization of ALL, particularly of the so called ‘B-other...

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Chiaretti et al. (2022) studied this question.

synapsesocial.com/papers/6ab5f6a51b6e853d2aad63fd https://doi.org/10.1080/10428194.2022.2148217

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ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. Biological and clinical findings

Key Points

Implication

Abstract

Discussion

Cite This Study

ZNF384 rearrangement is the most frequent genetic lesion in adult PH-negative and Ph-like-negative B-other acute lymphoblastic leukemia. Biological and clinical findings

Key Points

Implication

Abstract

Discussion

Cite This Study

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