Key result
Depressed patients with violent offenses showed more commission errors, slower responses, and altered P3 amplitudes and latencies compared to non-violent depressed patients and healthy controls.
Why the study?
Do EEG biomarkers during a Go/NoGo task differ in depressed patients with violent offenses compared to those without violent offenses and healthy controls?
Observational (n=84)
Do EEG biomarkers during a Go/NoGo task differ in depressed patients with violent offenses compared to those without violent offenses and healthy controls?
Reduced P3 amplitude in frontal-central regions and increased NoGo P3 latency may serve as electrophysiological biomarkers for predicting violent behavior in depressed patients.
May flag inhibition deficits for violence risk assessment in depression; leaves open prospective validation of P3 markers before clinical use.
Understanding the neurobiological correlates of behavioral inhibition in patients with depression who committed violent offenses could contribute to the prediction and prevention of violence. The present study recruited 29 depressed patients with violent offenses (VD group), 27 depressed patients without violent behavior (NVD group), and 28 healthy controls (HC group) to complete a visual Go/NoGo task, during which their responses and electroencephalography were simultaneously recorded using an event-related potentiometer. The results showed that the VD group made more commission errors and responded more slowly relative to the NVD and HC groups. The P3 amplitude of the VD group was reduced in the frontal and central brain regions compared to the HC group and increased in the parietal regions compared to the NVD group. In comparison to Go stimuli, NoGo stimuli induced longer P3 latencies in frontal regions in both the VD and NVD groups; however, this difference was not statistically significant in the HC group. These results provide electrophysical evidence of behavioral inhibition deficits in patients with depression, especially in those with violent behaviors. The reduced P3 amplitude in the frontal-central regions, increased P3 amplitude in the parietal regions, and increased NoGo P3 latency may be potential electrophysiological features that can predict violent behavior in patients with depression.
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Xian et al. (2024) conducted an observational in Depression (n=84). Depression with violent offenses vs. Depression without violent behavior and healthy controls was evaluated on Behavioral inhibition (commission errors, response time) and EEG P3 amplitude/latency during a Go/NoGo task. Depressed patients with violent offenses showed more commission errors, slower responses, and altered P3 amplitudes and latencies compared to non-violent depressed patients and healthy controls.
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