Tamoxifen-Induced Steatohepatitis

Letters1 May 1996Tamoxifen-Induced SteatohepatitisMarc Van Hoof, MD, Jaques Rahier, MD, and Yves Horsmans, MDMarc Van Hoof, MDClinique Saint-Luc; 1200 Brussels, BelgiumLouvain Medical School; 1200 Brussels, Belgium, Jaques Rahier, MDClinique Saint-Luc; 1200 Brussels, BelgiumLouvain Medical School; 1200 Brussels, Belgium, and Yves Horsmans, MDClinique Saint-Luc; 1200 Brussels, BelgiumLouvain Medical School; 1200 Brussels, BelgiumAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-9-199605010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Pratt and associates [1] reported the first case of tamoxifen-induced nonalcoholic steatohepatitis, emphasizing the importance of this diagnosis and the possibility of progression to cirrhosis.A 72-year-old woman had right mastectomy for breast cancer. Results of liver function tests and ultrasonography of the liver done before surgery were normal. She began receiving tamoxifen, 20 mg/d, after surgery. Her medical history was unremarkable. She consumed no alcohol and had no risk factors for the acquisition of viral hepatitis. Seven months after surgery, the patient had an alanine aminotransferase level of 35 IU/L (normal less than 25 IU/L) and ...References1. Pratt DS, Knox TA, Efban J. Tamoxifen-induced steatohepatitis. Ann Intern Med. 1995; 123:236. Google Scholar2. Diehl AM, Goodman Z, Ishak KG. Alcohol-like liver disease in nonalcoholics. Gastroenterology. 1985; 5:1056-62. Google Scholar3. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990; 11:74-80. Google Scholar4. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology. 1994; 107:1103-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Marc Van Hoof, MD; Jaques Rahier, MD; Yves Horsmans, MDAffiliations: Clinique Saint-Luc; 1200 Brussels, BelgiumLouvain Medical School; 1200 Brussels, Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byShort-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in miceCustomizable Microfluidic Origami Liver‐on‐a‐Chip (oLOC)Adipose tissuePemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver diseaseDrugs and ToxinsNAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and TreatmentMethylseleninic Acid and Grape Seed Extract Alleviate Tamoxifen Induce Hepatotoxicity in RatsReview article: drug-induced liver injury in the context of nonalcoholic fatty liver disease - a physiopathological and clinical integrated viewDrugs and ToxinsDrug-induced fatty liver disease: An overview of pathogenesis and managementApplication of urine proteomics for biomarker discovery in drug-induced liver injuryCancer ChemotherapyAdverse Effects of Hormones and Hormone Antagonists on the LiverDrugs and ToxinsLiver Disease Caused by DrugsThe association of nonalcoholic steatohepatitis and tamoxifen in patients with breast cancerCaffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in ratsRecent Developments in Liver PathologyFiebre, disnea e infiltrados pulmonares en una mujer de 50 años en tratamiento inmunodepresorReview article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver diseaseCancer Chemotherapy II: Atypical Hepatic InjuriesToremifene: An evaluation of its safety profileNASHPitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar−/−) miceDrug-induced steatohepatitisSerum leptin levels are associated with tamoxifen -induced hepatic steatosisEffects of Tamoxifen on Hepatic Fat Content and the Development of Hepatic Steatosis in Patients with Breast Cancer: High Frequency of Involvement and Rapid Reversal After Completion of Tamoxifen TherapyHepatitis tóxica asociada al uso de tamoxifeno.Presentación de un caso y revisión bibliográficaTamoxifen-Induced Cirrhotic ProcessNonalcoholic steatohepatitisAltered expression of fatty acid–metabolizing enzymes in aromatase-deficient miceTamoxifen-induced transient multifocal hepatic fatty infiltrationCirrhosis with steatohepatitis after adjuvant tamoxifenTamoxifen 1 May 1996Volume 124, Issue 9 Page: 855-856 Keywords Biopsy Fatty liver Hepatitis Inflammation Liver Liver fibrosis Liver function tests Nonalcoholic steatohepatitis Steatosis Surgery ePublished: 15 August 2000 Issue Published: 1 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...