Key result
Chronic physical and psychological stress impairs aortic contractility, with full recovery after one month.
Why the study?
The effects of chronic physical and psychological stress on vascular contractility and their reversibility were not fully understood.
Does chronic physical and psychological stress reduce the contractility of isolated rat aorta, and are these effects reversible?
Does chronic physical and psychological stress reduce the contractility of isolated rat aorta, and are these effects reversible?
Chronic physical and psychological stress similarly diminish vascular responsiveness in isolated rat aortas, an effect that is reversible after a one-month recovery period.
Answers are grounded in this paper and cite their sources.
Stress reduces rat aortic contractility reversibly after one month; extends preclinical data but leaves open human relevance.
: Background: The role of stress has been elucidated in cardiovascular disorders. The aim of this study was to determine and compare the effects of chronic physical and psychological stress on the contractility of isolated rat aorta and their reversibility.Materials and Methods: Wister rats were divided into 3 groups: control, physical stress, and psychological stress (n = 12). Animals were kept on 12-h/12-h light/dark cycles at 22 ± 2°C and had free access to food and water. Physical and psychological stress was induced using a communication box for 3 weeks. Physical stress was applied with electrical current (1 mA, 1 Hz, 10 sec/min) 1 hour twice daily. To assess the aortic response, the animals were anesthetized, abdominal aortas were removed, and the contractility response to potassium chloride and phenylephrine was measured with an isometric transducer. To study the reversibility of the effects, separate groups of stressed animals and a control group (n = 12 in each group) were kept for 1 month following the stress period, and the aortic responses were evaluated and compared.Results: In the stressed group, the aortic responses to potassium chloride and phenylephrine were significantly lower compared with the controls, whereas the corticosterone concentration was higher. Following a 1-month recovery, both values returned to normal.Conclusions: Chronic physical stress and psychological stress have similar effects on vascular responsiveness, which are reversible; these findings may be clinically important in the treatment of stress-related cardiovascular disorders. Implication for health policy/practice/research/medical education:Although the study has been performed in animal model, the findings will shed some more lights on the impacts of two types of stresses on cardiovascular system Please cite this paper as:Ghasemi A, Faraji F, Valaee F, Sedaghat K, Arabian M, Zahediasl S. Diminished Response of Isolated Aorta Following Chronic Physical and Psychological Stresses and its Reversibility in Rats. Int J Endocrinal Metab.2012; 10(1): 423-8. DOI: 10.5812/ijem.4062 Copyright © 2012 Kowsar M. P. Co. All rights reserved.
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Ghasemi et al. (2012) studied Stress-induced cardiovascular changes (n=72). Chronic physical and psychological stress vs. Control (no stress) was evaluated on Aortic contractility response to phenylephrine and potassium chloride (p=<0.05). Chronic physical and psychological stress significantly reduced isolated aortic contractility in response to phenylephrine and potassium chloride compared to controls (P < 0.05), an effect that was fully reversible after a 1-month recovery.
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