Hypopituitarism: Studies in Pituitary Tumors and Simmonds' Disease

Article1 March 1951HYPOPITUITARISM: STUDIES IN PITUITARY TUMORS AND SIMMONDS' DISEASEK. E. PASCHKIS, A. CANTAROWK. E. PASCHKISSearch for more papers by this author, A. CANTAROWSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-3-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hypophysectomized animal has proved to be the most valuable preparation in the study of pituitary physiology. Patients with destructive lesions of the anterior pituitary offer an opportunity for similar investigations of the physiology of the human pituitary gland. The studies reported in this paper were undertaken because relatively few such investigations have been published.MATERIAL AND METHODSThe 17 patients studied include cases of pituitary or parapituitary tumors (chromophobe adenomas, craniopharyngiomas) and nontumor cases (table 1). In addition to clinical examination and routine laboratory tests, the following studies were made: basal metabolic rate, serum cholesterol, insulin tolerance test,8salt...Bibliography1. CutlerPowerWilder HHMHRM: Concentrations of chloride, sodium and potassium in urine and blood. Their diagnostic significance in adrenal insufficiency, J. A. M. A. 111: 117-122, 1938. CrossrefGoogle Scholar2. D'AngeloGordon SAAS: The simultaneous detection of thyroid and thyrotropic hormone in vertebrate sera, Endocrinology 46: 39, 1950. CrossrefMedlineGoogle Scholar3. DaughadyJaffeWilliams WHHRH: Chemical assay for "cortin," J. Clin. Endocrinol. 8: 166, 1948. CrossrefGoogle Scholar4. DeaneGreep HWRO: A morphological and histochemical study of the rat's adrenal cortex after hypophysectomy with comments on the liver, Am. J. Anat. 79: 117-146, 1946. CrossrefMedlineGoogle Scholar5. EntemanChaikoffReichert CJLFL: Blood lipids of the hypophysectomized thyroidectomized dog, Endocrinology 30: 794, 1942. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 16, 1950.From the Division of Endocrine and Cancer Research and the Endocrine Clinic, Jefferson Medical College and Hospital, Philadelphia.Part of this work was presented at the Meeting of the Association for the Study of Internal Secretion, Atlantic City, 1947.We are indebted to Dr. B. Alpers and Dr. R. Jaeger for permission to study cases in the neurological and neurosurgical services, respectively. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byREFERENCESIsolated Thyrotropin Deficiency Review and Report of Three CasesFRANCIS N. LOHRENZ, M.D., RAFAEL FERNANDEZ, M.D., RICHARD P. DOE, M.D.Diagnostik der intrakraniellen GeschwülsteAn evaluation of graded hypophysectomy in man.A quantitative functional and anatomical studyHerz und Kreislauf bei Hypophysenvorderlappeninsuffizienz und nach HypophysektomieDie partielle VorderlappeninsuffizienzDie AdenohypophyseSimmonds' diseaseDie Keimdrüsen und ihre KrankheitenDie Bedeutung der Harn-Corticoid-Bestimmung f�r Diagnostik, operative Behandlung und Prognose von HypophysenadenomenClinical EndocrinologySolitary (‘monotropic’) thyrotropin deficiency with secondary hypothyroidismThe incidence of postpartum hypopituitarismDie NebennierePathophysiologie, Klinik und Behandlung der HypophysenadenomeDer klinische Wert der Nebennierenrindentestung mit Acth und Adrenalin 1 March 1951Volume 34, Issue 3Page: 669-677KeywordsAdenomasCholesterolHospitalsInsulinLaboratory testsLesionsPituitary glandPituitary tumorsSalts ePublished: 1 December 2008 Issue Published: 1 March 1951 PDF downloadLoading ...