Proteomics and Disease The Challenges for Technology and Discovery

The study of protein expression within distinct clinical disease settings is a major focus of biomedical research today. Powerful technology tools can now define the specific protein and peptide identities within complex clinical samples. However, we are only beginning to understand the relationships between form and function and between pathways and pathology. Correlating the clinical phenotype of disease with altered or dysfunctional classes of protein expression, structure, and function will ultimately provide improved treatment strategies.