Neuronal Machinery of Sleep Homeostasis in Drosophila

(Neuron 81, 860–872; February 19, 2014) We thank Douglas Armstrong, Hugo Bellen, Ronald Davis, Ulrike Heberlein, Martin Heisenberg, Liqun Luo, Gerald Rubin, and Helen Skaer for fly strains. In a regrettable oversight, some strains were credited to stock centers rather than the original sources. The correct attributions are as follows: cv-cMB03717, cv-cMB01956, cv-cDG20401 (Bellen et al., 2011Bellen H.J. Levis R.W. He Y. Carlson J.W. Evans-Holm M. Bae E. Kim J. Metaxakis A. Savakis C. Schulze K.L. et al.Genetics. 2011; 188: 731-743Crossref PubMed Scopus (264) Google Scholar, Venken et al., 2011Venken K.J.T. Schulze K.L. Haelterman N.A. Pan H. He Y. Evans-Holm M. Carlson J.W. Levis R.W. Spradling A.C. Hoskins R.A. Bellen H.J. Nat. Methods. 2011; 8: 737-743Crossref PubMed Scopus (420) Google Scholar); cv-cC524, UAS–cv-c (Denholm et al., 2005Denholm B. Brown S. Ray R.P. Ruiz-Gómez M. Skaer H. Hombría J.C.-G. Development. 2005; 132: 2389-2400Crossref PubMed Scopus (55) Google Scholar); UAS–cv-cRNAi (Billuart et al., 2001Billuart P. Winter C.G. Maresh A. Zhao X. Luo L. Cell. 2001; 107: 195-207Abstract Full Text Full Text PDF PubMed Scopus (180) Google Scholar); UAS–CD8-GFP (Lee and Luo, 1999Lee T. Luo L. Neuron. 1999; 22: 451-461Abstract Full Text Full Text PDF PubMed Scopus (1990) Google Scholar); C5–GAL4 (Yang et al., 1995Yang M.Y. Armstrong J.D. Vilinsky I. Strausfeld N.J. Kaiser K. Neuron. 1995; 15: 45-54Abstract Full Text PDF PubMed Scopus (289) Google Scholar); 104y–GAL4 (Rodan et al., 2002Rodan A.R. Kiger Jr., J.A. Heberlein U. J. Neurosci. 2002; 22: 9490-9501PubMed Google Scholar, Sakai and Kitamoto, 2006Sakai T. Kitamoto T. J. Neurobiol. 2006; 66: 821-834Crossref PubMed Scopus (48) Google Scholar); C205-GAL4 (Martin et al., 1999Martin J.R. Raabe T. Heisenberg M. J. Comp. Physiol. (A). 1999; 185: 277-288Crossref PubMed Scopus (155) Google Scholar); 23E10–GAL4 (Jenett et al., 2012Jenett A. Rubin G.M. Ngo T.-T.B. Shepherd D. Murphy C. Dionne H. Pfeiffer B.D. Cavallaro A. Hall D. Jeter J. et al.Cell Rep. 2012; 2: 991-1001Abstract Full Text Full Text PDF PubMed Scopus (824) Google Scholar); tubP–GAL80ts (McGuire et al., 2003McGuire S.E. Le P.T. Osborn A.J. Matsumoto K. Davis R.L. Science. 2003; 302: 1765-1768Crossref PubMed Scopus (952) Google Scholar). The article has been corrected online. Neuronal Machinery of Sleep Homeostasis in DrosophilaDonlea et al.NeuronFebruary 19, 2014In BriefDonlea et al. discover mutant flies with a broken sleep homeostat: after an all-nighter, these flies are unable to correct the accumulated sleep deficit. The mutation affects a Rho-GTPase-activating protein that regulates the electrical excitability of sleep-promoting neurons. Full-Text PDF Open Access